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Intracellular pathway of interleukin-2 receptors studied using immunogold electron microscopy
C McCrae1, L Maxwell, R Ceredig
1Department of Experimental Pathology, John Curtin School of Medical Research, Canberra, Australia.
Immunology and Cell Biology
|January 1, 1988
Abstract:
The fate of internalized interleukin-2 receptors (IL-2R) on proliferating T cell blasts and Lyt-2-/L3T4- thymocytes was studied by immunogold electron microscopy. Immediately following labeling, IL-2R were found in coated pits and with time there was sequential appearance of gold particles in smooth vesicles or endosomes, multivesicular bodies and lysosomes. Thus the IL-2R appears to be a member of cell surface receptors internalized by endocytosis via coated pits.