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Updated: Jan 19, 2026

Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units
Published on: September 18, 2016
Atroposelective Arene Formation by Carbene-Catalyzed Formal [4+2] Cycloaddition
Ke Xu1, Wenchang Li1, Shaoheng Zhu1
1School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, China.
Abstract:
Atroposelective arene formation is an efficient method to build axially chiral molecules with multi-substituted arenes. Reported here is an organocatalyzed atroposelective arene formation reaction by an N-heterocyclic carbene (NHC) catalyzed formal [4+2] cycloaddition of conjugated dienals and α-aryl ketones. This study expands the synthetic potential of NHC organocatalysis and provides a competitive pathway for the synthesis of axially chiral ligands, catalysts, and other functional molecules.
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