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Stage I hypertension is associated with impaired systolic function by strain imaging compared with prehypertension: A

Angela B S Santos1,2, Murilo Foppa1,2, Carolina Bertoluci1,2

  • 1Division of Cardiology, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Journal of Clinical Hypertension (Greenwich, Conn.)
|September 26, 2019
PubMed

Insights

Individuals with stage I hypertension show reduced left ventricular systolic function compared to those with prehypertension. This suggests even mild blood pressure elevation impacts subclinical cardiac function, highlighting the importance of early intervention for cardiovascular health.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Echocardiography

Background:

  • High blood pressure (BP) increases cardiovascular event risk, even at prehypertension (preHTN) and stage I hypertension (HTN) levels.
  • Reduced left ventricular (LV) systolic function, measured by global longitudinal strain (GLS), is known in HTN but not compared between preHTN and stage I HTN.

Purpose of the Study:

  • To compare LV systolic function (GLS) between individuals with preHTN and stage I HTN.
  • To identify clinical and echocardiographic correlates of GLS in stage I HTN patients.

Main Methods:

  • Analysis of baseline data from the PREVER study, including two randomized controlled trials (PREVER-prevention and PREVER-treatment).
  • GLS measurement from 2D echocardiograms in a subsample of participants (n=91 preHTN, n=105 stage I HTN) at baseline.
  • Comparison of GLS and clinical/echocardiographic parameters between groups.

Main Results:

  • Participants with stage I HTN exhibited significantly lower GLS (-17.5 ± 2.5%) compared to those with preHTN (-18.2 ± 2.4%).
  • In stage I HTN, lower GLS was associated with reduced e' and lower LV ejection fraction.
  • Clinical parameters were similar between groups, apart from expected BP differences.

Conclusions:

  • Stage I hypertension patients may already display impaired GLS compared to prehypertension individuals.
  • Even mild elevations in blood pressure can affect subclinical systolic function.
  • Findings underscore the potential impact of early BP changes on cardiac function.

Keywords:
echocardiographyhypertensionprehypertensionstrain

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