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Related Concept Videos

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Related Experiment Video

Updated: Jan 19, 2026

Analyzing the Effects of Stromal Cells on the Recruitment of Leukocytes from Flow
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Lung inflammatory environments differentially alter mesenchymal stromal cell behavior.

Soraia C Abreu1,2,3, Sara Rolandsson Enes1,4, Jacob Dearborn1

  • 1Department of Medicine, University of Vermont Larner College of Medicine, Burlington, Vermont.

American Journal of Physiology. Lung Cellular and Molecular Physiology
|September 26, 2019
PubMed
Summary
This summary is machine-generated.

Lung inflammation affects mesenchymal stromal cell (MSC) behavior. Different inflammatory environments, like acute respiratory distress syndrome (ARDS) versus cystic fibrosis (CF), alter MSCs

Keywords:
acute respiratory distress syndromecystic fibrosisinterleukin 6lung injurymesenchymal stromal (stem) cell

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Area of Science:

  • Immunology
  • Cell Biology
  • Regenerative Medicine

Background:

  • Mesenchymal stromal cells (MSCs) show therapeutic potential for lung injuries via anti-inflammatory actions.
  • The in vivo inflammatory environment may significantly influence MSC therapeutic efficacy.
  • Understanding how lung inflammation impacts MSC function is crucial for optimizing cell-based therapies.

Purpose of the Study:

  • To investigate the effects of distinct lung inflammatory conditions on human bone marrow-derived MSCs (hMSCs).
  • To assess how bronchoalveolar lavage fluid (BALF) from acute respiratory distress syndrome (ARDS) and non-ARDS (e.g., cystic fibrosis exacerbations) impacts hMSC gene expression and function.
  • To explore the role of interleukin-6 (IL-6) in mediating hMSC responses to inflammatory environments.

Main Methods:

  • hMSCs were cultured in vitro with BALF from ARDS and non-ARDS patients.
  • Time- and concentration-dependent effects on mRNA expression of inflammatory mediators were analyzed.
  • Gene expression patterns and the impact of conditioned media on monocyte phenotype were evaluated, including IL-6 neutralization.

Main Results:

  • Distinct, common, and disease-specific gene expression patterns were observed in hMSCs exposed to different BALF.
  • Interleukin-6 (IL-6) expression varied between conditions.
  • Conditioned media from non-ARDS BALF-exposed hMSCs were more effective at inducing an anti-inflammatory monocyte phenotype than those from ARDS BALF-exposed hMSCs; IL-6 neutralization partially restored this effect.

Conclusions:

  • Lung inflammatory environments can differentially modulate hMSC behavior and function.
  • Disease-specific inflammatory milieu may alter the therapeutic potential of MSCs.
  • Further research into these interactions is warranted to guide clinical applications of MSCs for lung diseases.