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Updated: Jan 19, 2026

Direct Mouse Trauma/Burn Model of Heterotopic Ossification
Published on: August 6, 2015
Heterotopic ossification: radiological and pathological review
Bilal Mujtaba1, Ahmed Taher1, Matthew J Fiala2
1Department of Diagnostic Imaging, University of Texas MD Anderson Cancer Center, Houston, USA.
Abstract:
Background Heterotopic Ossification (HO) is a common condition referring to ectopic bone formation in soft tissues. It has two major etiologies, acquired (more common) and genetic. The acquired form is closely related to tissue trauma. The exact pathogenesis of this disease remains unclear; however, there is ongoing research in prophylactic and therapeutic treatments that is promising. Conclusions Due to HO potential to cause disability, it is so important to differentiate it from other causes in order to establish the best possible management.
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