Related Experiment Video

Updated: Jan 19, 2026

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device
07:44

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device

Published on: May 2, 2025

835

Survival of infants ≤24 months of age with brain tumors: A population-based study using the SEER database

Claire Faltermeier1, Timothy Chai2, Sharjeel Syed2

  • 1Department of Neurosurgery, University of California, San Francisco, CA, United States of America.

Plos One
|September 26, 2019
PubMed

Insights

Survival for infant brain tumors has improved since the 1970s, but not for all types. Updated prognostication is needed for these pediatric brain tumors, considering changes in treatment and outcomes.

Area of Science:

  • Pediatric oncology
  • Neuro-oncology
  • Epidemiology

Background:

  • Infant brain tumors are the most common solid malignancy and leading cause of cancer-related death in children.
  • Existing epidemiological data is limited by small case numbers.
  • This study provides updated prognostication using population-based data.

Purpose of the Study:

  • To analyze survival trends for infant brain tumors.
  • To update prognostication based on contemporary and historical data.
  • To identify changes in management and outcomes over time.

Main Methods:

  • Population-based cohort analysis using the Surveillance, Epidemiology and End Results (SEER) database.
  • Inclusion of infants diagnosed with brain tumors between 1973 and 2013.
  • Stratification of survival rates by tumor type and decade, analyzing management trends.

Main Results:

  • Survival improved for most infant brain tumor types, excluding embryonal and choroid plexus tumors.
  • Ependymal tumors showed the most significant survival improvement, with 5-year survival increasing from 28% to 77% between the 1980s and 2000s.
  • Radiation use declined overall but increased for embryonal and ependymal tumors after 2000.

Conclusions:

  • Overall survival for infant brain tumors has improved, but not uniformly across all types.
  • Prognostication for infants with brain tumors requires updating due to evolving management and survival rates.
Abstract

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