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"Hierarchy" and "Holacracy"; A Paradigm of the Hematopoietic System

Takafumi Yokota1

  • 1Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan. yokotat@bldon.med.osaka-u.ac.jp.

Cells
|September 27, 2019
PubMed

The mammalian hematopoietic system has long been viewed as a hierarchical paradigm in which a small number of hematopoietic stem cells (HSCs) are located at the apex. HSCs were traditionally thought to be homogeneous and quiescent in a homeostatic state. However, recent observations, through extramedullary hematopoiesis and clonal assays, have cast doubt on the validity of the conventional interpretation. A key issue is understanding the characteristics of HSCs from different viewpoints, including dynamic physics and social network theory. The aim of this literature review is to propose a new paradigm of our hematopoietic system, in which individual HSCs are actively involved.

Keywords:
HSC-nicheHSC-unitextramedullary hematopoiesishematopoietic stem cellshierarchyholacracyunit networking diagram

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