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Updated: Jan 19, 2026

A Preclinical Model of Exertional Heat Stroke in Mice
Published on: July 1, 2021
Health Risks and Interventions in Exertional Heat Stress
Dieter Leyk1, Joachim Hoitz, Clemens Becker
1Bundeswehr Institute for Preventive Medicine; German Sport University Cologne; Bundeswehr Hospital Hamburg; Department of Geriatrics and Geriatric Rehabilitation at the Robert-Bosch-Hospital Stuttgart; Bundeswehr Hospital Koblenz; Institute and Policlinic for Occupational Medicine, Environmental Medicine and Prevention Research, University of Cologne.
Background:
With climate change, heat waves are expected to become more frequent in the near future. Already, on average more than 25 000 "heat deaths" are estimated to occur in Europe every year. However, heat stress and heat illnesses arise not just when ambient temperatures are high. Physical exertion increases heat production within the organism many times over; if not enough heat is lost, there is a risk of exertional heat stress. This review article discusses contributing factors, at-risk groups, and the diagnosis and treatment of heat illnesses.
Methods:
A selective literature search was carried out on PubMed. Current guidelines and expert recommendations were also included.
Results:
Apart from muscular heat production (>70% of converted energy), there are other factors that singly or in combination can give rise to heat stress: clothing, climate/acclimatization, and individual factors. Through its insulating properties, clothing reduces the evaporation of sweat (the most effective physiological cooling mechanism). A sudden heat wave, or changing the climate zone (as with air travel), increases the risk of a heat-related health event. Overweight, low fitness level, acute infections, illness, dehydration, and other factors also reduce heat tolerance. In addition to children, older people are particularly at risk because of their reduced physiological adaptability, (multi-)morbidity, and intake of prescription drugs. A heat illness can progress suddenly to life-threatening heat stroke. Successful treatment depends on rapid diagnosis and cooling the body down as quickly as possible. The aim is to reduce core body temperature to <40 °C within 30 minutes.
Conclusion:
Immediately effective cooling interventions are the only causal treatment for heat stroke. Time once lost cannot be made up. Prevention (acclimatization, reduced exposure, etc.) and terminating the heat stress in good time (e.g., stopping work) are better than any cure.
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