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Duvelisib for CLL/SLL and follicular non-Hodgkin lymphoma
Krish Patel1, Alexey V Danilov2, John M Pagel1
1Swedish Cancer Institute, Center for Blood Disorders and Stem Cell Transplantation, Seattle, WA; and.
Abstract:
Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and follicular lymphoma (FL) represent indolent malignancies characterized by multiple episodes of relapse. Therapy has centered on agents that largely target the B-cell receptor pathway. Duvelisib is a second-generation oral inhibitor of phosphoinositide-3 kinase, downstream of the B-cell receptor pathway, approved in the United States for relapsed CLL/SLL and FL. Duvelisib represents a highly active agent, and ongoing investigations, including fixed-duration drug combinations and alternative dosing schedules, are aimed at reducing immune-mediated toxicities.
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