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Left ventricular remodeling and dysfunction in obstructive sleep apnea : Systematic review and meta-analysis
Lei Yu1, Huajun Li2, Xianbao Liu2
1Department of Ultrasonography, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Herz
|September 27, 2019
Summary
Obstructive sleep apnea syndrome (OSAS) significantly impacts heart health, causing left ventricular enlargement and reduced systolic function. Early treatment for OSAS may help preserve cardiac structure and function.
Area of Science:
- Cardiology
- Sleep Medicine
- Internal Medicine
Background:
- Obstructive sleep apnea syndrome (OSAS) is linked to increased cardiovascular risks.
- Existing research suggests OSAS affects left ventricular structure and function, but large-scale trials are limited.
- This study systematically reviews the association between OSAS and left ventricular (LV) characteristics.
Purpose of the Study:
- To summarize the impact of OSAS on left ventricular structure and function.
- To provide a comprehensive overview of current evidence through meta-analysis.
Main Methods:
- A systematic review and meta-analysis of published studies up to March 2018.
- Searched major electronic databases including PubMed, Embase, and Cochrane.
- Assessed LV structure and function in OSAS patients using echocardiography data from 17 studies (747 OSAS patients, 426 controls).
Main Results:
- OSAS patients exhibited increased LV diastolic diameter, LV systolic diameter, and LV mass.
- A significant reduction in left ventricular ejection fraction (LVEF) was observed in OSAS patients.
- OSAS was associated with increased left atrial diameter and left atrial diameter volume index, with LVEF reduction correlating with OSAS severity.
Conclusions:
- Obstructive sleep apnea syndrome contributes to atrial dilatation and left ventricular hypertrophy, enlargement, and increased mass.
- OSAS negatively impacts left ventricular systolic function.
- Therapeutic interventions for OSAS may be crucial for maintaining cardiac structure and function.
Keywords:
Cardiac remodelingEchocardiographyHypoxiaLeft ventricular ejection fractionLeft ventricular hypertrophyMore Related Videos
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