Related Experiment Video
Updated: Jan 19, 2026

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
Published on: July 20, 2022
Left atrial structure and function predictors of recurrent fibrillation after catheter ablation: a systematic review
Gani Bajraktari1,2,3, Ibadete Bytyçi1,2, Michael Y Henein1,4,5
1Institute of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Insights
Catheter ablation for atrial fibrillation (AF) has high recurrence. Left atrial (LA) dilation (diameter >50mm, volume >150ml) or low LA strain (<19%) predicts AF recurrence post-ablation, indicating an unstable LA.
Area of Science:
- Cardiology
- Electrophysiology
- Medical Imaging
Background:
- Catheter ablation (CA) is a standard treatment for atrial fibrillation (AF).
- High recurrence rates persist after CA for AF.
- Predictors of AF recurrence after CA require identification.
Purpose of the Study:
- To identify left atrial (LA) structure and function indices predicting AF recurrence post-CA.
- To conduct a meta-analysis of existing studies on echocardiographic predictors of AF recurrence.
Main Methods:
- Systematic literature search of PubMed-Medline, EMBASE, Scopus, Google Scholar, and Cochrane Central Registry up to September 2017.
- Inclusion of 85 clinical trials and observational studies encompassing 16,126 patients.
- Pooled analysis of echocardiographic data to determine significant predictors of AF recurrence.
Main Results:
- Patients with AF recurrence exhibited larger LA diameter, LA volume index (LAVI), and LA area compared to those without recurrence.
- Lower LA strain and LA total emptying fraction (LA EF) were observed in patients with AF recurrence.
- Key predictors of AF recurrence included LA strain <19%, LA diameter ≥50 mm, and LAVmax >150 ml.
Conclusions:
- A dilated left atrium (diameter >50 mm, volume >150 ml) suggests instability.
- Reduced left atrial myocardial strain (<19%) indicates an unstable LA.
- These factors predict a lower likelihood of maintaining sinus rhythm after catheter ablation for atrial fibrillation.
Background:
Catheter ablation (CA) has become a conventional treatment for atrial fibrillation (AF), but remains with high recurrence rate. The aim of this meta-analysis was to determine left atrial (LA) structure and function indices that predict recurrence of AF.
Methods:
We systematically searched PubMed-Medline, EMBASE, Scopus, Google Scholar and the Cochrane Central Registry, up to September 2017 in order to select clinical trials and observational studies which reported echocardiographic predictors of AF recurrence after CA. Eighty-five articles with a total of 16 126 patients were finally included.
Results:
The pooled analysis showed that after a follow-up period of 21 ± 12 months, patients with AF recurrence had larger LA diameter with weighted mean difference (WMD: 2·99 ([95% CI 2·50-3·47], P<0·001), larger LA volume index (LAVI) maximal and LAVI minimal (P<0·0001 for both), larger LA area (P<0·0001), lower LA strain (P<0·0001) and lower LA total emptying fraction (LA EF) (P<0·0001) compared with those without AF recurrence. The most powerful LA predictors (in accuracy order) of AF recurrence were as follows: LA strain <19% (OR: 3·1[95% CI, -1.3-10·4], P<0·0001), followed by LA diameter ≥50 mm (OR: 2·75, [95% CI 1·66-4·56,] P<0·0001), and LAVmax >150 ml (OR: 2·25, [95% CI, 1.1-5·6], P = 0·0002).
Conclusions:
Based on this meta-analysis results, a dilated left atrium with diameter more than 50 mm and volume above 150 ml or myocardial strain below 19% reflect an unstable LA that is unlikely to hold sinus rhythm after catheter ablation for atrial fibrillation.
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