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Related Concept Videos

Urinary Bladder01:23

Urinary Bladder

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The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
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Related Experiment Video

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Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
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Ultracompliant Carbon Nanotube Direct Bladder Device.

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  • 1Department of Electrical and Engineering and Computer Science, University of Michigan, Ann Arbor, MI, 48109, USA.

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Researchers developed a flexible implantable device using carbon nanotubes (CNTs) to sense and electrically stimulate organs like the bladder. This technology shows promise for improving organ function and treating conditions like urinary retention.

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biomedical implantable devicebladder controlcarbon nanotubespinal cord injurystretchable electronics

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Area of Science:

  • Bioengineering
  • Materials Science
  • Medical Devices

Background:

  • Dynamic organ movement is crucial for physiological function.
  • Implantable devices are needed to sense organ motion and modulate function for therapeutic applications.
  • Conditions like urinary retention stem from incomplete bladder contractions, necessitating improved bladder management.

Purpose of the Study:

  • To design and demonstrate a flexible, implantable device for sensing and stimulating organ movement.
  • To evaluate the performance of a device utilizing carbon nanotube (CNT) and Ecoflex 00-50 materials.
  • To assess the potential of this device for therapeutic applications, particularly in bladder function.

Main Methods:

  • Fabrication of a thin-layer device using carbon nanotube (CNT) and Ecoflex 00-50.
  • Bench-top characterization of resistive and capacitive sensors under physiological conditions (5000 stretching cycles).
  • In vivo testing on feline bladders, measuring sensor resistance correlation with volume and electrical stimulation efficacy.

Main Results:

  • Resistive and capacitive sensors demonstrated stability over 5000 stretching cycles.
  • In vivo piezoresistive measurements showed a strong correlation between sensor resistance and bladder volume.
  • Electrical stimulation using platinum-silicone composite electrodes successfully induced bladder contractions.

Conclusions:

  • The developed device, using stretchable CNTs and platinum-silicone composites, is suitable for large-strain bioelectric applications.
  • This technology represents a significant step towards implantable devices that can sense and modulate dynamic organ states.
  • The device shows potential for treating conditions involving impaired organ function, such as urinary retention.