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Updated: Jan 19, 2026

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials
Published on: March 3, 2023
Antimicrobial activity of a continuously active disinfectant against healthcare pathogens
William A Rutala1, Maria F Gergen2, Emily E Sickbert-Bennett1,3
1Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
Abstract:
A novel disinfectant studied using an EPA protocol demonstrated sustained antimicrobial activity (ie, 3-5 log10 reduction) in 5 minutes after 24 hours for Staphylococcus aureus, vancomycin-resistant Enterococcus, Candida auris, carbapenem-resistant Escherichia coli and antibiotic-susceptible E. coli, and Enterobacter spp. Only ∼2 log10 reduction occurred with carbapenem-resistant Enterobacter spp and K. pneumoniae, and antibiotic-susceptible K. pneumoniae.
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