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Quantifying the Antifungal Activity of Peptides Against Candida albicans
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Recent Updates on Antifungal Peptides.

Deepika Sharma1, Gopal Singh Bisht2

  • 1Department of Pharmacy, Jaypee University of Information Technology, Waknaghat, Solan, Himachal Pradesh, 173234, India.

Mini Reviews in Medicinal Chemistry
|September 27, 2019
PubMed
Summary
This summary is machine-generated.

Rising antifungal resistance necessitates novel treatments. Natural antimicrobial peptides and their synthetic mimetics show promise, but toxicity and stability issues must be overcome for clinical use.

Keywords:
Antifungal peptidesantimicrobial peptidesfungal infectionsliving speciesmarine organismsmicrobial resistance.

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Area of Science:

  • Biochemistry
  • Microbiology
  • Pharmacology

Background:

  • Increasing frequency of antifungal resistance is a global health concern.
  • Natural antimicrobial peptides (AMPs) are key components of innate immunity with antifungal potential.
  • Existing antifungal therapies face challenges due to resistance and limited efficacy.

Purpose of the Study:

  • To review recent advancements in antifungal peptides (AFPs).
  • To explore novel mechanisms of action for antifungal compounds.
  • To discuss the potential of AFPs and their mimetics as future antifungal agents.

Main Methods:

  • Literature review of scientific databases for antifungal peptide research.
  • Analysis of studies on natural peptide isolation and synthesis of peptide mimetics.
  • Evaluation of peptide stability, toxicity, and efficacy data.

Main Results:

  • Numerous AFPs have been isolated from diverse natural sources.
  • Synthetic mimetics of AFPs have been developed using non-natural amino acids.
  • Challenges remain regarding the toxicity and stability of current AFPs.

Conclusions:

  • AFPs and their mimetics represent a promising avenue for combating antifungal resistance.
  • Further research is needed to optimize AFP properties for therapeutic applications.
  • Bridging the gap from laboratory research to clinical application is crucial for developing new antifungal drugs.