Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Drug Reactions01:27

Allergic Drug Reactions

1.4K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.4K
Hypersensitivities01:30

Hypersensitivities

7.2K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
7.2K
Pharmacovigilance01:19

Pharmacovigilance

1.6K
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
1.6K
Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

3.0K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
3.0K
Drug Regulation01:25

Drug Regulation

2.7K
Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
2.7K
Allergic Reactions02:06

Allergic Reactions

32.1K
Overview
32.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Successful Application of the Mast Cell Activation Test in Immediate Hypersensitivity to Amoxicillin.

Allergy·2026
Same author

Dendrimeric Antigens for Passive Mast Cell Activation in the Evaluation of Amoxicillin Allergy.

Allergy·2026
Same author

Updated Treatment of Non-Steroidal Anti-Inflammatory Drug-Exacerbated Respiratory Disease: How to Decide on Aspirin Therapy After Desensitization or Biologics? When? How? An EAACI Task Force Report.

Allergy·2026
Same author

Development of Betalactam-Predictor: A Clinical Decision Tool for Delabeling Low-Risk Betalactam Allergy Patients. Initial Validation in Penicillin Allergy.

Allergy·2026
Same author

Long-Term Effect of Allergen Immunotherapy in Responder Local Allergic Rhinitis Patients: Symptom Control, and Prevention of Asthma and Allergic Sensitizations.

Allergy·2025
Same author

Diagnosis of Quinolone Hypersensitivity: An EAACI Position Paper.

Allergy·2025
Same journal

Deficiency of Mitochondrial Fatty Acid Enzyme, CPT1A, Underlies Airway Epithelial Barrier Dysfunction in Severe Asthma.

Allergy·2026
Same journal

Surgical Management of Non-Allergic Rhinitis-An EAACI Task Force Position Paper.

Allergy·2026
Same journal

Serotonin Degradation and Lipid Metabolism Regulate Human Tc2 Cell Effector Functions.

Allergy·2026
Same journal

EAACI Guidelines on Environmental Science for Allergy and Asthma-Evidence-Based Recommendations for Prevention and Public Health Action to Mitigate the Impact of Pollen Exposure on Respiratory Allergy.

Allergy·2026
Same journal

Diet-Microbiome-Immune Interactions at the Gut Mucosa in Food Allergy: Mechanisms, Gaps, and Therapeutic Implications.

Allergy·2026
Same journal

Melittin in AllergoOncology: From Honey Bee Venom to Anti-Cancer Therapeutic Innovation-An EAACI Position Paper.

Allergy·2026
See all related articles

Related Experiment Video

Updated: Jan 19, 2026

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
10:22

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Published on: September 16, 2011

34.1K

Recent developments and highlights in drug hypersensitivity.

Cristobalina Mayorga1,2,3, Tahia D Fernandez1, Maria Isabel Montañez1,3

  • 1Allergy Research Group, Instituto de Investigación Biomédica de Málaga-IBIMA-ARADyAL, Málaga, Spain.

Allergy
|September 27, 2019
PubMed
Summary
This summary is machine-generated.

Drug hypersensitivity reactions (DHRs) are a growing health concern. Accurate diagnosis and de-labeling of patients are crucial for effective management and reducing healthcare costs.

Keywords:
allergy diagnosisallergy treatmentbasic mechanismsdrug allergyepidemiology

More Related Videos

Induction and Monitoring of Active Delayed Type Hypersensitivity DTH in Rats
13:26

Induction and Monitoring of Active Delayed Type Hypersensitivity DTH in Rats

Published on: July 19, 2007

18.3K
Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.3K

Related Experiment Videos

Last Updated: Jan 19, 2026

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
10:22

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Published on: September 16, 2011

34.1K
Induction and Monitoring of Active Delayed Type Hypersensitivity DTH in Rats
13:26

Induction and Monitoring of Active Delayed Type Hypersensitivity DTH in Rats

Published on: July 19, 2007

18.3K
Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.3K

Area of Science:

  • Clinical Immunology
  • Allergy and Immunology
  • Pharmacovigilance

Background:

  • Drug hypersensitivity reactions (DHRs) are increasingly prevalent, posing significant health and financial burdens.
  • Mislabelling DHRs, either as allergic or non-allergic, complicates patient management and healthcare.
  • Accurate diagnostic approaches and improved stakeholder/patient training are essential for DHR management.

Purpose of the Study:

  • To review recent advancements in understanding and managing DHRs.
  • To highlight the importance of accurate diagnosis and de-labeling of DHR patients.
  • To emphasize strategies for preventing DHRs and improving patient outcomes.

Main Methods:

  • Comprehensive review of recent literature (last 2 years) on DHRs.
  • Analysis of risk factors, diagnostic methods, mechanisms, and management strategies.
  • Evaluation of de-labeling and prevention techniques, including allergy cards.

Main Results:

  • DHRs represent a significant and increasing public health issue.
  • Accurate diagnosis and de-labeling are critical for appropriate patient care.
  • Allergy cards are effective in preventing inadvertent DHR induction.

Conclusions:

  • Improved diagnostic accuracy and de-labeling of DHR patients are necessary.
  • Enhanced training for healthcare professionals and patients can reduce mislabelling.
  • Effective management of DHRs requires a multi-faceted approach including prevention and accurate diagnosis.