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Association between dyslipidemia and CCL2 in patients undergoing hemodialysis

Wander Valadares de Oliveira Junior1, Ana Paula Ferreira Silva1, Roberta Carvalho de Figueiredo1

  • 1Campus Centro Oeste-Universidade Federal de São João Del-Rei, Brazil.

Cytokine
|September 27, 2019
PubMed

Insights

C-C Motif Chemokine Ligand 2 (CCL2) plasma levels are linked to dyslipidemia in hemodialysis patients. This finding suggests CCL2 may play a role in cardiovascular disease development for these individuals.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Immunology

Background:

  • Hemodialysis (HD) patients face elevated cardiovascular disease (CVD) risks, including heart attack, stroke, and heart failure.
  • C-C Motif Chemokine Ligand 2 (CCL2), also known as monocyte chemotactic protein-1 (MCP-1), is implicated in inflammatory processes and its levels increase in dyslipidemic chronic kidney disease (CKD) patients on HD.

Purpose of the Study:

  • To investigate the association between plasma C-C Motif Chemokine Ligand 2 (CCL2) levels and dyslipidemia in patients undergoing hemodialysis (HD).

Main Methods:

  • A cross-sectional study included 160 Brazilian HD patients.
  • CCL2 plasma levels were quantified using capture ELISA.
  • Linear regression analysis, adjusted for CVD risk factors, was employed to assess the association between CCL2 and dyslipidemia.

Main Results:

  • A statistically significant association was found between CCL2 plasma levels and dyslipidemia (P=0.029).
  • This association remained significant after adjusting for confounding variables like age, gender, BMI, diabetes, HD duration, and weight gain (P=0.045).

Conclusions:

  • Elevated CCL2 levels are associated with dyslipidemia in HD patients, suggesting a potential role for this cytokine in the pathogenesis of cardiovascular complications.
  • Further understanding of this mechanism could lead to novel therapeutic strategies to mitigate CVD in HD patients.
Abstract

Keywords:
Cardiovascular risk factorChronic kidney diseaseDyslipidemiaHemodialysisMCP-1/CCL2

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