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STAT3 and STAT5 Activation in Solid Cancers.

Sebastian Igelmann1,2, Heidi A Neubauer3, Gerardo Ferbeyre4,5

  • 1Department of Biochemistry and Molecular Medicine, Université de Montréal, C.P. 6128, Succ. Centre-Ville, CRCHUM, Montréal, QC H3C 3J7, Canada. sebastian.igelmann@umontreal.ca.

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Summary
This summary is machine-generated.

Signal Transducer and Activator of Transcription (STAT)3 and 5 proteins have dual roles in cancer, acting as both oncogenes and tumor suppressors. Their context-dependent function in solid tumors impacts patient survival and cancer progression.

Keywords:
apoptosiscell cycleinflammationmitochondriasolid cancersstemnesstumor suppression

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Area of Science:

  • Molecular Biology
  • Cancer Research
  • Signal Transduction

Background:

  • Signal Transducer and Activator of Transcription (STAT)3 and 5 proteins are key mediators of cytokine receptor signaling.
  • These STAT proteins regulate gene expression and mitochondrial functions, influencing cellular processes.
  • Their involvement in cancer is complex, with roles as both oncogenes and tumor suppressors.

Purpose of the Study:

  • To review the role of STAT3/5 activation in solid cancers.
  • To summarize the association between STAT3/5 signaling and patient survival.
  • To elucidate the context-dependent functions of STAT3/5 in tumor progression.

Main Methods:

  • Literature review of STAT3/5 roles in solid cancers.
  • Analysis of molecular mechanisms underlying STAT3/5 oncogenic activity.
  • Summary of tumor suppressor pathways interacting with STAT3/5 signaling.

Main Results:

  • STAT3/5 signaling regulates genes involved in cell cycle, cell death, inflammation, and stemness.
  • STAT3 mitochondrial functions are critical for cancer cell transformation.
  • Numerous tumor suppressor pathways, including PIAS3, TMF/ARA160, miRNAs, p19ARF/p53, and SOCS1/3, modulate STAT3/5 activity.

Conclusions:

  • The dual role of STAT3/5 in cancer is context-dependent, influenced by interactions with various signaling pathways.
  • Cancer-associated mutations and epigenetic alterations can shift the balance between STAT3/5's oncogenic and tumor-suppressive functions.
  • Understanding these complex interactions is crucial for deciphering STAT3/5's impact on tumor progression and patient outcomes.