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DASH diet decreases CXCL4 plasma concentration in patients diagnosed with coronary atherosclerotic lesions

Magdalena Makarewicz-Wujec1, Jan Henzel2, Mariusz Kruk2

  • 1Department of Clinical Pharmacy and Pharmaceutical Care, Medical University of Warsaw, Poland.

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|September 28, 2019
PubMed

Insights

The DASH diet intervention significantly reduced CXCL4 chemokine levels in patients with coronary artery disease (CAD). This lifestyle change shows promise for managing atherosclerosis progression.

Area of Science:

  • Cardiology
  • Nutrition Science
  • Biochemistry

Background:

  • Coronary atherosclerosis is linked to elevated CXCL4 chemokine levels.
  • Lifestyle interventions are crucial for managing cardiovascular disease.
  • The DASH diet is a recognized dietary pattern for cardiovascular health.

Purpose of the Study:

  • To assess the impact of a DASH diet-based lifestyle intervention on plasma CXCL4 concentrations in patients with coronary atherosclerosis.
  • To evaluate the effect of dietary intervention on cardiovascular risk markers.

Main Methods:

  • A randomized controlled trial (NCT02571803) involving patients with stable coronary artery disease (CAD).
  • Interventional group received DASH diet counseling for 6 months; control group had no dietary intervention.
  • Body composition, high-sensitivity C-reactive protein, and CXCL4 levels were measured.

Main Results:

  • The DASH diet group showed significant reductions in body weight and CXCL4 concentration (p < 0.0001).
  • A significant decrease in high-sensitivity C-reactive protein was also observed in the DASH group (p < 0.05).
  • No significant changes were noted in the control group.

Conclusions:

  • The DASH diet effectively reduces CXCL4 concentration in patients with stable CAD.
  • Further research is needed to confirm these findings and assess the impact on atherosclerotic plaque.
  • This study highlights the potential of dietary interventions in managing cardiovascular disease markers.
Abstract

Keywords:
AtherosclerosisChemokine CXCL4DASH dietInflammation

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