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Graham Roberts Study protocol: first 'trials within cohort study' for bladder cancer.
Harriet Wylie1, Fidelma Cahill1, Aida Santaolalla1
1Translational Oncology and Urology Research, King's College London, London, UK.
BMJ Open
|September 28, 2019
Summary
The Graham Roberts Study establishes a prospective cohort using the trials within cohort (TwiCs) design for bladder cancer research. This infrastructure will address clinical, mechanistic, and supportive care questions in bladder cancer patients.
Area of Science:
- Urology
- Oncology
- Clinical Trials
Background:
- Bladder cancer research requires robust infrastructure.
- The trials within cohort (TwiCs) design offers advantages for clinical studies.
- The Graham Roberts Study aims to fill this gap.
Purpose of the Study:
- To establish a prospective cohort infrastructure for bladder cancer research.
- To facilitate a wide range of clinical, mechanistic, and supportive care investigations.
- To leverage the trials within cohort (TwiCs) design for efficient data collection.
Main Methods:
- Prospective cohort study utilizing the TwiCs design.
- Recruitment of patients aged 18+ with new or recurrent bladder cancer.
- Collection of validated questionnaires at baseline and 12-month intervals.
Main Results:
- The study is designed to collect comprehensive data on bladder cancer patients.
- Validated instruments will assess quality of life, fatigue, mental health, physical activity, and diet.
- Data will be available for future research and collaboration.
Conclusions:
- The Graham Roberts Study provides a valuable infrastructure for bladder cancer research.
- The TwiCs design enables efficient data collection for diverse research questions.
- This study will contribute to advancing clinical, mechanistic, and supportive care knowledge in bladder cancer.
