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Complete Genome Sequence of Klebsiella pneumoniae Siphophage Skenny

Jacob Gramer1, Sarah Kenny1, Heather Newkirk1

  • 1Center for Phage Technology, Texas A&M University, College Station, Texas, USA.

Microbiology Resource Announcements
|September 28, 2019
PubMed

Insights

Researchers sequenced the genome of siphophage Skenny, a virus that infects the antibiotic-resistant bacterium Klebsiella pneumoniae. This finding aids in understanding phage-host interactions and developing new antimicrobial strategies.

Area of Science:

  • Microbiology
  • Genomics
  • Virology

Background:

  • Klebsiella pneumoniae is a significant Gram-negative opportunistic pathogen.
  • It is a primary cause of antibiotic-resistant nosocomial infections.

Purpose of the Study:

  • To describe the genome sequence of siphophage Skenny.
  • To provide insights into the genetic makeup of phages infecting K. pneumoniae.

Main Methods:

  • Genome sequencing of siphophage Skenny.

Main Results:

  • The Skenny genome comprises 78 genes.
  • Skenny is phylogenetically related to T1-like phages, specifically Klebsiella phages KPN N141 and MezzoGao.

Conclusions:

  • The characterization of the Skenny genome contributes to the understanding of Klebsiella phage diversity.
  • This information may support the development of phage-based therapies against K. pneumoniae infections.

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