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Suppressor cells in human decidua.

S Daya, D A Clark, C Devlin

    American Journal of Obstetrics and Gynecology
    |January 15, 1985
    PubMed
    Summary
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    Human decidual lymphocytes exhibit suppressor cell activity, crucial for preventing maternal immune rejection of the allogeneic embryo. This finding suggests a mechanism to prevent spontaneous abortion during pregnancy.

    Area of Science:

    • Immunology
    • Reproductive Biology
    • Cell Biology

    Background:

    • Decidual suppressor cells are known in mice, preventing maternal cytotoxic cell infiltration at implantation sites.
    • Absence of these cells correlates with fetal resorption in intraspecies pregnancies and infiltration in interspecies pregnancies.
    • The presence and role of similar suppressor cells in human allopregnancies remain to be fully elucidated.

    Purpose of the Study:

    • To investigate the presence and function of suppressor cells in human decidua during successful pregnancies.
    • To determine if decidual lymphocytes can inhibit maternal immune responses against the allogeneic fetus.

    Main Methods:

    • Decidua samples were collected from human gestations at 13-15 weeks and term.
    • Lymphocytes were isolated from decidual tissues.

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  • The ability of these lymphocytes to suppress the response of autologous peripheral blood lymphocytes to concanavalin A was assessed.

    • Main Results:

    • Decidual lymphocytes from all eight (13-15 weeks) and a majority of term pregnancies demonstrated significant suppressor activity.
    • Suppression was observed across different concentrations of decidual lymphocytes tested at term.
    • These findings indicate the presence of functional suppressor cells in the human decidua.

    Conclusions:

    • Suppressor cells are present in human decidua during successful allopregnancies.
    • These cells likely play a critical role in modulating the maternal immune system.
    • Their function may be essential in preventing maternal immunologic attack on the allogeneic embryo, thus preventing spontaneous abortion.