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Related Experiment Video

Updated: Jan 19, 2026

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Published on: October 16, 2013

Assessing colitis ex vivo using optical coherence elastography in a murine model.

Achuth Nair¹, Chih Hao Liu¹, Manmohan Singh¹

¹Department of Biomedical Engineering, University of Houston, Houston, TX, USA.

Quantitative Imaging in Medicine and Surgery

|September 28, 2019

Summary

Optical coherence elastography (OCE) detects differences in colon tissue stiffness and optical properties, aiding in ulcerative colitis (UC) diagnosis. This advanced imaging technique offers higher resolution for early detection of inflammatory bowel disease (IBD).

Keywords:

Inflammatory bowel diseases (IBDs)elasticity imaging techniques optical coherence elastography (OCE)optical coherence tomography (OCT)tissue biomechanical properties ulcerative colitis (UC)

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Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model

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Last Updated: Jan 19, 2026

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Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model

Published on: February 14, 2021

Area of Science:

Biomedical Optics
Medical Imaging
Gastroenterology

Background:

Ulcerative colitis (UC), a form of inflammatory bowel disease (IBD), affects the colon and is often diagnosed via colonoscopy.
Current ultrasonic techniques have limited spatial resolution, leading to potential underdiagnosis of colitis.
Optical techniques like optical coherence tomography (OCT) offer higher resolution, and OCT-based elastography (OCE) can assess biomechanical properties.

Purpose of the Study:

To investigate the utility of OCT-based elastography (OCE) for detecting differences in colon tissue properties related to ulcerative colitis.
To evaluate OCE's capability in imaging biomechanical properties of small mammal colon tissue for disease modeling.

Main Methods:

Induced elastic waves in ex vivo mouse colon tissue using a focused air-pulse.
Detected elastic waves with a phase-stabilized swept source OCE system to determine tissue stiffness.
Analyzed elastic wave dispersion and OCT structural images for additional contrast between control and diseased tissues.

Main Results:

Demonstrated significant differences (P<0.05) in stiffness between control (Young's modulus 11.8±8.0 kPa) and colitis samples (5.1±1.5 kPa).
Observed distinct differences in optical properties, including OCT signal standard deviations and spatial frequency decay slopes.
Identified variations in the dispersion curve slopes between control (1.5 mm) and colitis (0.8 mm) samples.

Conclusions:

OCE effectively distinguishes between healthy and diseased colon tissue based on stiffness and optical properties.
Healthy colon tissue was found to be stiffer than diseased tissue, a key indicator for UC detection.
OCE provides valuable structural and biomechanical contrast for identifying UC-like disease in colon tissue.