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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Platinum-mediated B-H methoxylation of bis(pyrazolyl)borate
Shrinwantu Pal1, Brian O Patrick, Jennifer A Love
1Department of Chemistry, The University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada. jenlove@chem.ubc.
Abstract:
A new bis(pyrazolyl)dihydridoborato diphenylplatinum(ii) complex was found to react with methanol to form H2 and a new diphenylplatinum(ii) complex supported by bis(pyrazolyl)dimethoxyborate. When performed in CD3OD, in addition to the expected installation of OCD3 fragments on the B-center and concomitant formation of H-D, deuteration of PtII(C6H5)2 fragments was observed. In contrast, dissolution of the bis(pyrazolyl)dimethoxyborato diphenylplatinum(ii) complex in CD3OD led to neither deuteration of PtII(C6H5)2 fragments nor substitution of B-bound methoxy fragments. A mechanism discussing the role of the PtII-center is presented.
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