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[Rheumatism and the mind-A mini review]
D Linsmayer1, P-K Neidlinger2, D F Braus2
1Klinik- und Poliklinik für Psychiatrie und Psychotherapie, Helios Dr. Horst Schmidt Kliniken Wiesbaden, Ludwig-Erhard-Straße 100, 65199, Wiesbaden, Deutschland. Denise.Linsmayer@helios-gesundheit.de.
Der Orthopade
|September 28, 2019
Summary
Mental and rheumatic disorders share common stress and inflammation pathways. Integrated treatment addressing both physical and psychological aspects is crucial for improved patient outcomes and quality of life.
Area of Science:
- Psychoneuroimmunology
- Rheumatology
- Psychiatry
Background:
- Rheumatic and mental health disorders frequently co-occur, often leading to delayed diagnosis and reduced quality of life.
- Comorbidities negatively impact patient outcomes and therapeutic success.
- Understanding shared mechanisms is vital for effective management.
Purpose of the Study:
- To investigate evidence for common pathophysiological mechanisms between rheumatic and mental disorders.
- To explore therapeutic implications of these shared pathways.
Main Methods:
- Analysis of recent findings, reviews, and foundational literature.
- Synthesis of current data on the interplay between stress, inflammation, and disease.
Main Results:
- Stress and inflammation mutually influence depressive disorders, anxiety disorders, chronic pain, and rheumatic diseases.
- A strong bidirectional relationship exists between immunological and neuronal processes regulating stress response.
Conclusions:
- Effective therapy requires an interdisciplinary approach integrating rheumatic care with multimodal pharmacological and psycho-social interventions.
- Consideration of potential drug and therapy interactions is essential for comprehensive patient management.
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