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Blood Pressure Variability and Therapeutic Implications in Hypertension and Cardiovascular Diseases

Chiara Nardin1, Marcello Rattazzi2, Paolo Pauletto3

  • 1Department of Medicine-DIMED, Medicina Interna I^-Ca' Foncello Hospital, University of Padova, Via Ospedale, 31100, Treviso, Italy. cnardin88@gmail.com.

High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension
|September 28, 2019
PubMed

Insights

Blood pressure variability (BPV) impacts cardiovascular risk. Calcium channel blockers effectively control BPV, but more research is needed on optimal drug combinations for improved patient outcomes.

Area of Science:

  • Cardiology
  • Pharmacology
  • Hypertension Research

Background:

  • Blood pressure (BP) exhibits continuous dynamic oscillations, termed blood pressure variability (BPV).
  • Elevated BPV is linked to target organ damage, increased cardiovascular (CV) risk, and mortality.
  • BPV management is emerging as a crucial adjunct to lowering mean BP in hypertension.

Purpose of the Study:

  • To review the therapeutic implications of managing blood pressure variability.
  • To summarize the effects of various antihypertensive drug classes on different BPV metrics.

Main Methods:

  • Systematic review of existing literature on antihypertensive medications and their impact on BPV.
  • Analysis of studies evaluating short-term and long-term BPV reduction.

Main Results:

  • Most first-line antihypertensive drugs can reduce both short-term and long-term BPV.
  • Calcium channel blockers (CCBs), in monotherapy or combination, demonstrate superior efficacy in BPV control.
  • Further investigation is required to determine optimal drug combinations based on CV risk stratification.

Conclusions:

  • CCBs are highly effective in managing blood pressure variability.
  • Personalized antihypertensive strategies incorporating BPV control are essential.
  • Randomized trials are needed to guide drug selection for improved cardiovascular outcomes.

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