[Progress in cerebrospinal fluid proteome technology and its clinical application]

Area of Science:

• Neuroscience
• Biochemistry
• Proteomics

Background:

• Cerebrospinal fluid (CSF) directly interfaces with the central nervous system (CNS), making it a crucial biofluid for disease biomarker discovery.
• The unique position of CSF enables the identification of biomarkers for various neurological disorders.

Purpose of the Study:

• To review recent advancements in proteomics technologies applicable to CSF analysis.
• To highlight the clinical applications of CSF proteomics in diagnosing and understanding CNS diseases.

Main Methods:

• Comprehensive literature search on CSF proteomics.
• Analysis of recent technological innovations in mass spectrometry and related techniques for CSF biomarker identification.
• Review of studies demonstrating the clinical utility of CSF proteomic profiles.

Main Results:

• Significant progress has been made in high-throughput proteomics technologies enabling deeper and more comprehensive analysis of the CSF proteome.
• Numerous potential biomarkers for neurodegenerative diseases, CNS infections, and other neurological conditions have been identified.
• Emerging applications include early diagnosis, disease monitoring, and personalized treatment strategies.

Conclusions:

• Proteomics of cerebrospinal fluid is a rapidly evolving field with immense potential for CNS disease diagnostics.
• Continued technological development and clinical validation are essential to fully realize the diagnostic and therapeutic promise of CSF biomarkers.