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Related Concept Videos

Proteomics01:33

Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Related Experiment Video

Updated: Jan 19, 2026

Comprehensive Workflow of Mass Spectrometry-based Shotgun Proteomics of Tissue Samples
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Comprehensive Workflow of Mass Spectrometry-based Shotgun Proteomics of Tissue Samples

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[Mouse liver proteome database].

Yang Liu1, Jinwen Feng2, Wanlin Liu3

  • 1Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.

Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology
|September 28, 2019
PubMed
Summary
This summary is machine-generated.

Researchers created the Mouse Liver Portal, a comprehensive database of mouse liver proteome expression. This resource aids in understanding liver function across various physiological and pathological states.

Keywords:
databaseliverproteomics

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Area of Science:

  • Biochemistry
  • Genomics
  • Proteomics

Background:

  • The liver is a vital metabolic organ in mammals.
  • Understanding liver proteome expression is crucial for deciphering its physiological and pathological mechanisms.
  • Advancements in liquid chromatography tandem mass spectrometry have generated extensive proteomics data.

Purpose of the Study:

  • To systematically collect and consolidate mouse liver proteomics data.
  • To establish a centralized, accessible database for liver proteome information.
  • To facilitate research into liver function and disease.

Main Methods:

  • Systematic collection of 834 mouse liver proteomics experiments.
  • Development of the Mouse Liver Portal (http://mouseliver.com) database.
  • Inclusion of data across diverse physiological and pathological conditions.

Main Results:

  • The Mouse Liver Portal now houses a comprehensive collection of mouse liver proteomics data.
  • The database covers various conditions including gender, age, circadian rhythm, cell type, partial hepatectomy, and non-alcoholic fatty liver.
  • It details protein expression changes, identifies differentially expressed proteins, and maps associated biological processes and networks.

Conclusions:

  • The Mouse Liver Portal serves as a valuable, comprehensive resource for the scientific community.
  • It provides critical data and insights for advancing liver biology research.
  • The database supports the exploration of signal transduction and regulatory networks in the liver.