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Vesico-urethral function in Huntington's chorea.

J S Wheeler, D S Sax, R J Krane

British Journal of Urology

|February 1, 1985

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This study reveals a unique urodynamic pattern in Huntington's chorea patients experiencing incontinence. It involves specific muscle contractions during bladder filling and voiding, offering new insights into neurogenic bladder dysfunction.

Area of Science:

Neuro-urology
Neurology
Urodynamics

Background:

Huntington's chorea is a neurodegenerative disorder.
Urological complaints, particularly incontinence, can affect patients with Huntington's chorea.
The neuro-urological basis of incontinence in this population requires further investigation.

Purpose of the Study:

To evaluate the neuro-urological status of patients with Huntington's chorea presenting with urological complaints.
To identify characteristic urodynamic findings associated with incontinence in Huntington's chorea.

Main Methods:

Neuro-urological evaluation was performed on six patients with Huntington's chorea.
Urodynamic studies were conducted to assess bladder function and pelvic floor muscle activity.

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Analysis focused on identifying specific patterns of muscle contractions during bladder filling and voiding.

Main Results:

Four patients exhibited detrusor hyperreflexia with a normal sphincter.
Two patients had normal urodynamic studies, suggesting non-organic causes for incontinence.
A novel urodynamic pattern was observed: choreiform contractions of abdominal perineal floor muscles during bladder filling, with selective suppression during detrusor contraction.

Conclusions:

A distinct urodynamic pattern exists in Huntington's chorea patients with incontinence.
This pattern involves involuntary, choreiform muscle contractions affecting pelvic floor function.
Findings contribute to understanding the neuro-urological underpinnings of incontinence in Huntington's chorea.