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Updated: Aug 9, 2026

Streamlined 3D Cerebellar Differentiation Protocol with Optional 2D Modification
Published on: December 9, 2017
Modifications of CFU-S differentiation pathways by pluripoietins: influence of treatment protocols
Abstract:
Similar total doses of Ara-C given as a single injection or given in a fractionated protocol have reverse effects on CFU-S differentiation pathways. Whereas a single dose of 20 mg channels CFU-S towards erythropoiesis, 5 X 5 mg given at 8 or 24 hour intervals channels CFU-S to granulopoiesis and megakaryocytopoiesis. It therefore seems possible to manipulate CFU-S differentiation not only by varying the inducing agents but also by varying the protocols using the same agent. Hypotheses to explain the mechanisms of CFU-S regulation are presented.
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