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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Bone Disorders01:29

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Hormones and Bone Tissue01:17

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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Related Experiment Video

Updated: Jan 18, 2026

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
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Bisphosphonates use in Pachydermoperiostosis.

Rakesh Kumar Jagdish1, M K Bhatnagar2, Ayush Malhotra3

  • 1Assistant Professor of Medicine and Incharge Rheumatology Clinic, Santosh Medical College and Hospital, Ghaziabad, Uttar Pradesh.

The Journal of the Association of Physicians of India
|September 29, 2019
PubMed
Summary

Pachydermoperiostosis, a rare genetic disorder, often causes skin and bone issues. Early use of bisphosphonates showed promising results for managing this condition.

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Area of Science:

  • Genetics
  • Dermatology
  • Rheumatology

Background:

  • Pachydermoperiostosis is a rare genetic disorder characterized by skin thickening, digital clubbing, and bone pain.
  • Current treatment options for pachydermoperiostosis are often limited and yield unsatisfactory outcomes.

Observation:

  • A case of pachydermoperiostosis presented with typical symptoms including clubbing, bone pain, and skin changes.
  • The patient's condition was managed with bisphosphonates, leading to encouraging results.

Findings:

  • Bisphosphonates demonstrated efficacy in managing the symptoms of pachydermoperiostosis.
  • Parenteral administration of bisphosphonates yielded positive outcomes in the observed case.

Implications:

  • Parenteral bisphosphonates represent a potential therapeutic option for pachydermoperiostosis.
  • Early consideration of bisphosphonate therapy may improve patient outcomes in pachydermoperiostosis.