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Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a

Juliana C Gomes1, Lorenzo Cianni2, Jean Ribeiro2

  • 1Instituto de Química de São Carlos, Universidade de São Paulo, São Carlos, São Paulo, Brazil.

Bioorganic & Medicinal Chemistry
|September 29, 2019
PubMed

Keywords:
Covalent inhibitorCruzainCysteine proteaseGroup efficiencyLipophilic efficiencyNonadditivityStructure-activity relationship

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