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Published on: June 18, 2018
Association between cognitive performance and SYT1-rs2251214 among women with cocaine use disorder
Thiago Wendt Viola1, Jaqueline Bohrer Schuch2, Diego Luiz Rovaris3,4
1Developmental Cognitive Neuroscience Lab, School of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul, PUCRS, Avenida Ipiranga 6691 - Predio 11, sala 926, Jardim Botânico, Porto Alegre, RS, Brazil.
Abstract:
The SNP rs2251214 of the SYT1 gene was recently associated with externalizing phenotypes, including ADHD and cocaine use disorder (CUD). Here, we investigated whether SYT1-rs2251214 could also be implicated with cognitive performance variations among women with CUD. Results showed that G homozygous (n = 146) have lower cognitive performance in the Stroop, Trail Making and Matrix Reasoning tests compared with A-allele carriers (n = 64), suggesting that rs2251214 may influence the severity of cognitive impairments in CUD.
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