The CroCo cross-link converter: a user-centred tool to convert results from cross-linking mass spectrometry
Julian Bender1, Carla Schmidt1
1Martin Luther University Halle-Wittenberg, Institute for Biochemistry and Biotechnology, Interdisciplinary Research Center HALOmem, Charles Tanford Protein Center, 06120 Halle (Saale), Germany.
Motivation:
A variety of search engines exists for the identification of peptide spectrum matches after cross-linking mass spectrometry experiments. The resulting diversity in output formats complicates data validation and visualization as well as exchange with collaborators, particularly from other research areas.
Results:
Here, we present CroCo, a user-friendly standalone executable to convert cross-linking results to a comprehensive spreadsheet format. Using this format, CroCo can be employed to generate input files for a selection of the commonly utilized validation and visualization tools.
Availability And Implementation:
The source-code is freely available under a GNU general public license at https://github.com/cschmidtlab/croco. The standalone executable is available and documented at https://cschmidtlab.github.io/CroCo.
Supplementary Information:
Supplementary data are available at Bioinformatics online.
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