Human encephalitis complicated with bilateral acute retinal necrosis associated with pseudorabies virus infection: A
Yuwei Wang1, Hong Nian2, Ziwei Li1
1Department of Ophthalmology, Qilu Hospital of Shandong University, Shandong University, 107 West Wenhua Road, Lixia District, Jinan, Shandong 250012, PR China; Shandong University Cheeloo College of Medicine, 44 West Wenhua Road, Lixia District, Jinan, Shandong 250012, PR China.
Abstract:
We report the case of a patient who presented with viral encephalitis and a pulmonary infection complicated with bilateral acute retinal necrosis after direct contact with diseased swine. Next-generation sequencing of the cerebrospinal fluid and vitreous humor detected pseudorabies virus (PRV) simultaneously. Intravenous acyclovir and dexamethasone treatment improved the symptoms of encephalitis, and vitrectomy surgery with silicone oil tamponade was used to treat the retinal detachment. This case implies that PRV can infect humans; thus, self-protection is imperative when there is contact with animals.
