Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Maxam-Gilbert Sequencing01:05

Maxam-Gilbert Sequencing

12.6K
In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
Challenges of the Maxam-Gilbert Method
The...
12.6K
Sanger Sequencing01:57

Sanger Sequencing

773.3K
DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
773.3K
Next-generation Sequencing03:00

Next-generation Sequencing

97.9K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
97.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Association of Sleeping Duration and Sleep Problems With All-Cause Mortality Among a Cohort of Industrial Workers Followed Up for 36 Years.

American journal of industrial medicine·2026
Same author

Correction: Molecular Aharonov-Bohm-type interferometers based on porphyrin nanorings.

Chemical science·2025
Same author

Wound localization and housing conditions dictate repair dynamics and scar formation.

Lab animal·2025
Same author

Molecular Aharonov-Bohm-type interferometers based on porphyrin nanorings.

Chemical science·2025
Same author

Positive impact of cladribine tablets on reducing brain atrophy in patients with relapsing-remitting multiple sclerosis: A longitudinal study.

Multiple sclerosis (Houndmills, Basingstoke, England)·2025
Same author

DNA origami scaffold promoting nerve guidance and regeneration.

Biotechnology journal·2024

Related Experiment Video

Updated: Jan 18, 2026

Rare Event Detection Using Error-corrected DNA and RNA Sequencing
10:36

Rare Event Detection Using Error-corrected DNA and RNA Sequencing

Published on: August 3, 2018

12.6K

Simulating the Monty Hall problem in a DNA sequencing machine.

Noam Mamet1, Gil Harari1, Adva Zamir1

  • 1Augmanity, Rehovot, Israel.

Computational Biology and Chemistry
|September 29, 2019
PubMed
Summary
This summary is machine-generated.

This study uses DNA sequencing to solve the counter-intuitive Monty Hall problem, simulating over 12 million games. High-throughput sequencing offers a novel approach for DNA computing and problem-solving.

Keywords:
DNA computingMonty Hall ProblemNext generation sequencing

More Related Videos

Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection
07:16

Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection

Published on: February 9, 2024

1.5K
Ultra-long Read Sequencing for Whole Genomic DNA Analysis
10:34

Ultra-long Read Sequencing for Whole Genomic DNA Analysis

Published on: March 15, 2019

23.9K

Related Experiment Videos

Last Updated: Jan 18, 2026

Rare Event Detection Using Error-corrected DNA and RNA Sequencing
10:36

Rare Event Detection Using Error-corrected DNA and RNA Sequencing

Published on: August 3, 2018

12.6K
Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection
07:16

Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection

Published on: February 9, 2024

1.5K
Ultra-long Read Sequencing for Whole Genomic DNA Analysis
10:34

Ultra-long Read Sequencing for Whole Genomic DNA Analysis

Published on: March 15, 2019

23.9K

Area of Science:

  • Computational Biology
  • Genomics
  • DNA Computing

Background:

  • The Monty Hall problem is a classic probability puzzle with a counter-intuitive solution.
  • Simulating complex decision problems computationally can be challenging.

Purpose of the Study:

  • To simulate and prove the solution to the Monty Hall problem using a novel DNA sequencing approach.
  • To demonstrate the potential of high-throughput DNA sequencing for encoding and solving computational problems.

Main Methods:

  • Representing all Monty Hall problem scenarios using DNA oligonucleotides.
  • Implementing gameplay decisions through targeted sequencing of these oligonucleotides.
  • Utilizing a high-throughput DNA sequencing machine to simulate over 12 million independent games in a single run.

Main Results:

  • Successfully simulated and validated the counter-intuitive solution of the Monty Hall problem.
  • Demonstrated the feasibility of encoding decision problems within DNA sequences.
  • Achieved a high-throughput simulation exceeding 12 million games.

Conclusions:

  • High-throughput DNA sequencing is a viable and powerful tool for simulating and solving complex decision problems.
  • This work opens new avenues for DNA computing by enabling novel encoding schemes.
  • The study validates the counter-intuitive solution of the Monty Hall problem through a physical simulation.