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Leptin rs7799039 polymorphism is associated with multiple sclerosis risk in Kuwait
Mohammed Dashti1, Raed Alroughani2, Sindhu Jacob1
1Genetics and Bioinformatics department, Dasman Diabetes Institute, Kuwait City, Kuwait.
Multiple Sclerosis and Related Disorders
|September 29, 2019
Summary
Lower leptin levels are observed in Multiple sclerosis (MS) patients. The LEP rs7799039AA variant is identified as a risk factor for developing MS.
Area of Science:
- Neuroimmunology
- Genetics
- Endocrinology
Background:
- The role of leptin in Multiple sclerosis (MS) pathogenesis and clinical outcomes remains unclear.
- Investigating genetic variants in leptin (LEP) and leptin receptor (LEPR) may elucidate their influence on MS.
Purpose of the Study:
- To determine if common variants in LEP and LEPR genes affect MS risk and leptin levels.
- To analyze the association between leptin levels and MS in a Kuwaiti population.
Main Methods:
- A case-control study involving 169 MS patients and 100 healthy controls.
- Genotyping of LEP rs7799039 and LEPR rs1137101 using Taqman assays.
- Quantification of plasma leptin levels via enzyme-linked immunosorbent assay.
Main Results:
- Leptin levels were significantly lower in MS patients compared to controls (p=0.012).
- The LEP rs7799039AA genotype was associated with an increased risk of MS (OR=2.52, p=0.003).
- No significant association was found between the studied markers and MS disability, severity, or treatment response.
Conclusions:
- The LEP rs7799039AA variant is a risk factor for MS in the Kuwaiti population.
- Reduced leptin levels are characteristic of MS patients.
- Further research should account for factors affecting leptin levels to clarify its role in MS pathogenesis and progression.
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