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Analgesia and Pain Management

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...

General Anesthesia: Overview

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Related Experiment Video

Updated: Jan 18, 2026

Intracranial Pharmacotherapy and Pain Assays in Rodents

Intracranial Pharmacotherapy and Pain Assays in Rodents

Published on: April 9, 2019

Anesthesia and Chronic Pain Management.

Anuj Malhotra¹, Mourad Shehebar¹, Yury Khelemsky²

¹Department of Anesthesiology, Perioperative and Pain Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, KCC 8th Floor, Box 1010, New York, NY 10029, USA.

Otolaryngologic Clinics of North America

|September 30, 2019

Summary

Chronic pain development is unclear, but severe acute pain may lead to it. Early, multidisciplinary pain management in head and neck surgery patients can potentially reduce chronic pain.

Keywords:

Anesthesia Chronic pain Postoperative pain

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Last Updated: Jan 18, 2026

Intracranial Pharmacotherapy and Pain Assays in Rodents

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Published on: April 9, 2019

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Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research

Published on: January 5, 2024

Area of Science:

Pain Medicine
Otolaryngology
Anesthesiology

Background:

The etiology of chronic pain remains largely unknown.
Chronic postoperative pain is frequently associated with severe acute postoperative pain.
Head and neck pain presents a complex diagnostic and therapeutic challenge.

Purpose of the Study:

To explore the link between acute and chronic pain in head and neck surgery.
To investigate the potential of early multimodal analgesia in preventing chronic pain.

Main Methods:

Review of existing literature on chronic pain development.
Analysis of pain management strategies in otolaryngologic patients.
Focus on the role of multidisciplinary teams and multimodal analgesic regimens.

Main Results:

A strong correlation exists between severe acute postoperative pain and the development of chronic pain.
Early intervention with multimodal analgesia shows promise in mitigating chronic pain.

Conclusions:

Multimodal analgesic regimens, when implemented early by multidisciplinary teams, may help prevent and manage chronic pain in otolaryngologic patients.
Further research is warranted to fully elucidate the mechanisms of chronic pain and optimize treatment strategies.