Related Experiment Video
Updated: Jan 18, 2026
Multimodality Diagnosis of Mesenteric Ischemia
Published on: July 21, 2023
May Nesfatin-1 be a Biomarker in Acute Mesenteric Ischemia?
Cihad Tatar1, Fatih Alper Ahlatci2, Ufuk Oguz Idiz1
1Departmet of General Surgery, Istanbul Training and Research Hospital, Istanbul, Turkey.
Objective:
To investigate the diagnostic value of nesfatin-1 in cases of intestinal ischemia and ischemia/reperfusion.
Study Design:
An experimental study.
Place And Duration Of Study:
The Experimental Animals Laboratory of Bezmialem University, in June 2018.
Methodology:
Twenty-one healthy male Sprague Dawley rats were randomly divided into three groups of 7 rats each. In group 1: 1-hour intestinal ischemia followed by 5-hour reperfusion was performed. In group 2: rats were subjected to 6-hour intestinal ischemia. In group 3: rats underwent laparotomy and closure without performing any further procedure. Changes in leukocyte count, amylase, blood sugar, LDH, SGOT, CRP, and nesfatin-1 levels were determined. For histopathological examination, a small intestinal sample was taken and preserved in 10% formaldehyde.
Results:
Nesfatin-1 value in group 2 was significantly higher than that in group 1 and group 3 (p=0.005, and p <0.001 respectively). Nesfatin-1 value in group 1 was significantly higher than that in group 3. A significant (r = 0.864/p <0.001) positive correlation was observed between nesfatin-1 value and pathology score. The pathology score of group 2 was significantly higher than that of group 1 and group 3 (p <0.001).
Conclusion:
Serum nesfatin-1 can be a biomarker in acute mesenteric ischemia.
More Related Videos
07:05Visualization of Neutrophil Extracellular Traps in Mesenteric Venules After Mesenteric Ischemia-Reperfusion Injury via Intravital Microscopy
Published on: September 27, 2024
08:41Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
Published on: March 24, 2023
Related Concept Videos
01:25Ultrasound II: Endoscopic Ultrasound and FibroScan
Endoscopic Ultrasound (EUS):
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...