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Risk of CYP2C9 induction analyzed by a relative factor approach with human hepatocytes

Chihiro Endo-Tsukude1, Motohiro Kato2, Akihisa Kaneko2

  • 1Translational Research Division, Chugai Pharmaceutical Co., Ltd., 2-1-1 Nihonbashi-muromachi, Chuo-ku, Tokyo 103-8324, Japan; Department of Medical Oncology and Translational Research, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-Honmachi, Chuo-ku, Kumamoto 862-0973, Japan; National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.

Drug Metabolism and Pharmacokinetics
|October 1, 2019
PubMed

Keywords:
CYP2C9CYP3A4Clinical studyEnzyme inductionHepatocyte

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