Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

7.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Zwitterionic peptide dendrimer-based nanocarriers with enhanced stability and biocompatibility for cancer therapy.

Colloids and surfaces. B, Biointerfaces·2026
Same author

Piezoelectric stepped-plate resonators vibrating at lateral modes for direct viscosity determination in liquids.

Microsystems & nanoengineering·2026
Same author

Author Correction: Polyrotaxane-based supramolecular theranostics.

Nature communications·2026
Same author

A conserved fungal Egh16-like effector suppresses host defense by disrupting ATP binding of wheat MPK3.

Journal of integrative plant biology·2026
Same author

Epitaxial Yttrium Doped Hafnia with Giant Remnant Polarization for Ferroelectric Tunnel Junction Artificial Synapses and Neuromorphic Computing.

ACS nano·2026
Same author

Correction to: Preclinical evaluation of an <sup>18</sup>F-trifluoroborate methionine derivative for glioma imaging.

European journal of nuclear medicine and molecular imaging·2026

Related Experiment Video

Updated: Jan 18, 2026

Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting
07:54

Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting

Published on: March 25, 2019

8.7K

Tumour microenvironment-responsive semiconducting polymer-based self-assembly nanotheranostics.

Zhen Yang1,2, Yunlu Dai3, Lingling Shan2

  • 1Department of Ultrasound in Medicine, the Second Affiliated Hospital of Zhejiang University School of Medicine. No. 88 Jiefang Road, Hangzhou.310009, P. R. China. huangpintong@zju.edu.cn.

Nanoscale Horizons
|October 1, 2019
PubMed
Summary
This summary is machine-generated.

This study introduces a novel nanoplatform for cancer theranostics, combining drug delivery and multimodal imaging. The platform enables targeted chemotherapy and photothermal therapy, leading to complete tumor eradication with reduced side effects.

More Related Videos

Fabrication of Spherical and Worm-shaped Micellar Nanocrystals by Combining Electrospray, Self-assembly, and Solvent-based Structure Control
06:16

Fabrication of Spherical and Worm-shaped Micellar Nanocrystals by Combining Electrospray, Self-assembly, and Solvent-based Structure Control

Published on: February 11, 2018

20.2K
Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time
14:36

Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time

Published on: August 26, 2009

11.6K

Related Experiment Videos

Last Updated: Jan 18, 2026

Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting
07:54

Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting

Published on: March 25, 2019

8.7K
Fabrication of Spherical and Worm-shaped Micellar Nanocrystals by Combining Electrospray, Self-assembly, and Solvent-based Structure Control
06:16

Fabrication of Spherical and Worm-shaped Micellar Nanocrystals by Combining Electrospray, Self-assembly, and Solvent-based Structure Control

Published on: February 11, 2018

20.2K
Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time
14:36

Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time

Published on: August 26, 2009

11.6K

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Developing advanced nanoplatforms for cancer theranostics is crucial for improving treatment efficacy and diagnosis.
  • Multimodal imaging and combination therapy offer synergistic benefits in cancer management.
  • Stimuli-responsive drug delivery systems can enhance therapeutic outcomes and minimize off-target toxicity.

Purpose of the Study:

  • To design and evaluate a novel Pt prodrug and gadolinium ion-loaded nanoplatform for multimodal imaging-guided cancer therapy.
  • To investigate the pH and thermal sensitivity of the nanoplatform for controlled drug release and combination therapy.
  • To assess the diagnostic and therapeutic efficacy of the nanoplatform in a tumor model.

Main Methods:

  • Fabrication of a pH and thermal-sensitive polymer-based nanoplatform loaded with a Pt prodrug and gadolinium ions.
  • Characterization of nanoparticle stability, drug release kinetics under different pH and temperature conditions.
  • Evaluation of multimodal imaging capabilities (photoacoustic/magnetic resonance/positron emission tomography) and T1 relaxivity enhancement.
  • Assessment of in vivo tumor accumulation, chemo-photothermal combination therapy efficacy, and tumor eradication.

Main Results:

  • The nanoplatform demonstrated stability in physiological environments and controlled drug release under tumor-specific acidic pH and near-infrared (NIR) irradiation.
  • Significant enhancement in magnetic resonance (MR) signal (~3-fold increase in T1 relaxivity) was observed in the acidic tumor microenvironment.
  • The nanoparticles exhibited excellent tumor accumulation and achieved complete tumor eradication with low-power NIR laser irradiation.
  • Reduced side effects on normal organs due to targeted drug release.

Conclusions:

  • The developed nanoplatform offers a promising strategy for multimodal imaging-guided chemo-photothermal combination therapy.
  • The stimuli-responsive nature of the nanoplatform allows for precise control over drug release and therapeutic effects.
  • This approach provides a new avenue for effective cancer diagnosis and treatment with enhanced safety profile.