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Gene expression analysis in scars treated with silicone cream: a case series
Robin Kikuchi1, Abdullah J Khalil2, Christopher I Zoumalan1,3
1Private Practice, Aesthetic and Reconstructive Oculoplastic Surgery, Beverly Hills, CA, USA.
Scars, Burns & Healing
|October 1, 2019
Summary
Topical silicone cream, SKN2017B, showed favorable gene expression for wound healing in post-surgical scars. This suggests improved scar appearance and healing compared to untreated scars.
Area of Science:
- Dermatology and Regenerative Medicine
- Molecular Biology and Genetics
Background:
- Adult scar tissue exhibits visible scarring, unlike fetal tissue.
- Topical silicone creams are known to improve scar appearance.
- This study investigates the genetic expression of scar tissue treated with silicone cream (SKN2017B) versus no treatment.
Observation:
- A case series involved women undergoing abdominoplasty, with scars treated by topical silicone, SKN2017B, or left untreated.
- Punch biopsies were collected after four weeks for RNA sequencing.
- Gene expression in treated scars was compared to baseline healthy abdominal skin.
Findings:
- SKN2017B-treated scars showed a lower collagen type I to III ratio.
- Favorable gene expression for wound healing, including lower fibroblast activation protein alpha, lysyl oxidase, and cartilage oligomeric matrix protein, was observed with SKN2017B.
- SKN2017B treatment resulted in higher expression of fibronectin type III domain containing 1 and matrix metallopeptidase 9.
Implications:
- Topical silicone creams, particularly SKN2017B, may promote more favorable genetic expression for wound healing.
- These findings suggest potential for improved scar management and aesthetic outcomes.
- Further research is warranted to confirm these trends in larger studies.
