Correlation between ¹⁸F-FDG maximum standardized uptake value with CD147 expression in lung adenocarcinomas: a...

Area of Science:

• Oncology
• Nuclear Medicine
• Molecular Imaging

Background:

• Cluster of differentiation 147 (CD147) promotes tumor growth and chemotherapy resistance in lung adenocarcinoma, partly via enhanced glycolysis.
• 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) metabolic parameters like SUVmax, SUVmean, MTV, and TLG offer non-invasive insights into tumor glucose metabolism.

Purpose of the Study:

• To investigate the correlation between 18F-FDG PET metabolic parameters and CD147 expression in lung adenocarcinoma.
• To assess the prognostic value of CD147 expression in resectable lung adenocarcinoma patients.

Main Methods:

• Retrospective analysis of 89 chemotherapy-naive lung adenocarcinoma patients undergoing 18F-FDG PET/CT before surgery.
• Quantification of PET metabolic parameters (SUVmax, SUVmean, MTV, TLG) and assessment of CD147 expression via immunohistochemistry.
• Statistical analysis to compare PET parameters for predicting CD147 expression, followed by survival analysis.

Main Results:

• SUVmax showed a significant correlation with CD147 expression and was the primary predictor.
• A SUVmax cut-off of 9.77 achieved 85.1% sensitivity and 64.3% specificity for predicting CD147 positivity.
• CD147 expression correlated with tumor differentiation and metastasis, and was associated with shorter overall survival (OS).

Conclusions:

• 18F-FDG PET SUVmax serves as a simple, non-invasive marker for predicting CD147 expression in lung adenocarcinoma.
• CD147 is identified as an independent prognostic factor influencing the overall survival of lung adenocarcinoma patients post-surgery.