Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Alveolar hypoventilation treated with medroxyprogesterone.

J Milerad, H Lagercrantz, O Löfgren

    Archives of Disease in Childhood
    |February 1, 1985
    PubMed
    Summary

    Medroxyprogesterone acetate effectively treated alveolar hypoventilation syndrome in infants, improving breathing and reducing the need for assisted ventilation. This treatment offers a potential therapeutic option for pediatric respiratory control disorders.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A lateral-to-mesial organization of human ventral visual cortex at birth.

    Brain structure & function·2018
    Same author

    Site tenacity and nomadism in Tengmalm's owl (Aegolius funereus (L.)) in relation to cyclic food production.

    Oecologia·2017
    Same author

    Cycles in voles and small game in relation to variations in plant production indices in Northern Sweden.

    Oecologia·2017
    Same author

    Cranial ultrasound and MRI at term age in extremely preterm infants.

    Archives of disease in childhood. Fetal and neonatal edition·2009
    Same author

    Therapeutic hypothermia can be induced and maintained using either commercial water bottles or a "phase changing material" mattress in a newborn piglet model.

    Archives of disease in childhood·2009
    Same author

    Mode of delivery modulates physiological and behavioral responses to neonatal pain.

    Journal of perinatology : official journal of the California Perinatal Association·2008

    Area of Science:

    • Pediatric Pulmonology
    • Respiratory Physiology
    • Neonatal Medicine

    Background:

    • Alveolar hypoventilation syndrome (AHS) in infants presents with severe apnea and impaired gas exchange.
    • Children with AHS exhibit reduced ventilatory responses to carbon dioxide and nocturnal hypoxemia.
    • Assisted ventilation is often required for managing critical apneic episodes in affected infants.

    Observation:

    • Two pediatric patients, aged 1 and 20 months, were diagnosed with alveolar hypoventilation syndrome.
    • Both infants experienced recurrent severe apneic episodes necessitating ventilatory support.
    • Baseline assessments revealed diminished carbon dioxide ventilatory response and significant nocturnal hypoxemia.

    Findings:

    • Treatment with medroxyprogesterone acetate normalized the ventilatory response to carbon dioxide.
    • Medroxyprogesterone acetate eliminated the need for assisted ventilation in both children.
    • While oxygen and carbon dioxide levels improved, they remained mildly abnormal during sleep.

    Implications:

    • Medroxyprogesterone acetate demonstrates therapeutic potential for pediatric alveolar hypoventilation syndrome.
    • This treatment may offer an alternative to long-term assisted ventilation in select pediatric cases.
    • Further research is warranted to fully understand long-term efficacy and potential side effects like pituitary suppression.

    Related Experiment Videos