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Transcriptome Analysis Identifies an Attenuated Local Immune Response in Invasive Nonfunctioning Pituitary Adenomas
Yong Hwy Kim1,2, Jung Hee Kim2,3,4
1Department of Neurosurgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Endocrinology and Metabolism (Seoul, Korea)
|October 1, 2019
Summary
Invasive nonfunctioning pituitary adenomas (NFPAs) show distinct molecular differences from non-invasive types. Suppressed immune response and TGF-β signaling are linked to increased invasiveness in NFPAs.
Area of Science:
- Endocrinology
- Molecular Biology
- Oncology
Background:
- Invasive nonfunctioning pituitary adenomas (NFPAs) present significant clinical challenges due to high complication rates and poor prognosis.
- Understanding the molecular basis of NFPA invasiveness is crucial for improving patient outcomes.
Purpose of the Study:
- To identify distinct molecular signatures differentiating invasive from non-invasive NFPAs.
- To elucidate the role of gene expression profiles in pituitary adenoma invasiveness.
Main Methods:
- RNA sequencing was performed on 14 NFPA tissue samples (3 non-invasive, 11 invasive).
- Bioinformatics analyses included differential gene expression, gene ontology, and pathway analysis.
Main Results:
- 700 differentially expressed genes were identified between invasive and non-invasive NFPAs.
- Down-regulated genes in invasive NFPAs indicated an attenuated local immune response and suppressed transforming growth factor-β (TGF-β) signaling.
- Overexpression of CLDN9 and down-regulation of IGFBP5, DAPK1, and TIMP3 were associated with invasiveness.
Conclusions:
- Invasive NFPAs exhibit unique gene expression profiles compared to non-invasive counterparts.
- Suppression of local immune response and TGF-β signaling pathways may contribute to NFPA invasiveness.
