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Synthesis and biological evaluation of a MraY selective analogue of tunicamycins
Kazuki Yamamoto1, Toyotaka Sato2, Yuta Hikiji1
1Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Nucleosides, Nucleotides & Nucleic Acids
|October 1, 2019
Abstract:
Tunicamycins, which are nucleoside natural products, inhibit both bacterial phospho-N-acetylmuraminic acid (MurNAc)-pentapeptide translocase (MraY) and human UDP-N-acetylglucosamine (GlcNAc): polyprenol phosphate translocase (GPT). The improved synthesis and detailed biological evaluation of an MraY-selective inhibitor, 2, where the GlcNAc moiety was modified to a MurNAc amide, has been described.
