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Updated: Jan 18, 2026

Evaluating Skilled Prehension in Mice Using an Auto-Trainer
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Evaluating Skilled Prehension in Mice Using an Auto-Trainer

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Evaluating Skilled Prehension in Mice Using an Auto-Trainer.

Robert Hubbard1, Jason Dunthorn2, Richard J O'Brien3

  • 1Department of Neurology, Johns Hopkins University.

Journal of Visualized Experiments : Jove
|October 1, 2019
PubMed
Summary
This summary is machine-generated.

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This study introduces a new method for training mice in a reach-to-grasp task. An automated trainer system simplifies data collection for grasping behaviors in mice.

Area of Science:

  • Neuroscience
  • Animal Behavior
  • Behavioral Neuroscience

Background:

  • Assessing fine motor skills in rodents is crucial for understanding neurological processes.
  • Existing methods for evaluating prehension (reach-to-grasp) behaviors in mice can be labor-intensive and difficult to standardize.

Purpose of the Study:

  • To develop and validate a novel, automated method for training and assessing reach-to-grasp behaviors in naïve mice.
  • To facilitate efficient and reliable data collection on reaching and grasping kinematics in rodent models.

Main Methods:

  • Mice were housed individually and introduced to a food retrieval task through a cage slot.
  • Training involved manual manipulation of food pellets to encourage paw extension and grasping.
  • An automated trainer was subsequently used to deliver food and record successful/failed grasping attempts.

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Automated Rat Single-Pellet Reaching with 3-Dimensional Reconstruction of Paw and Digit Trajectories
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Automated Rat Single-Pellet Reaching with 3-Dimensional Reconstruction of Paw and Digit Trajectories

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Related Experiment Videos

Last Updated: Jan 18, 2026

Evaluating Skilled Prehension in Mice Using an Auto-Trainer
05:01

Evaluating Skilled Prehension in Mice Using an Auto-Trainer

Published on: September 12, 2019

6.0K
In Vivo Wireless Optogenetic Control of Skilled Motor Behavior
07:52

In Vivo Wireless Optogenetic Control of Skilled Motor Behavior

Published on: November 22, 2021

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Automated Rat Single-Pellet Reaching with 3-Dimensional Reconstruction of Paw and Digit Trajectories
07:52

Automated Rat Single-Pellet Reaching with 3-Dimensional Reconstruction of Paw and Digit Trajectories

Published on: July 10, 2019

15.0K

Main Results:

  • The described method successfully trained naïve mice to perform a prehension task.
  • The automated trainer system enabled efficient data acquisition on reaching and grasping success rates.
  • This approach minimizes experimenter effort while maximizing data collection potential.

Conclusions:

  • The developed method provides a standardized and efficient approach for studying reach-to-grasp behaviors in mice.
  • This automated system is valuable for preclinical research in motor control and neurological disorders.
  • The technique allows for scalable and reproducible collection of kinematic data in rodent models.