Finger length ratio in longevity populations

Area of Science:

• Human longevity research
• Anthropometry
• Genetics and aging

Background:

• The finger length ratio, specifically the 2D:4D ratio, is a proposed indicator of prenatal androgen exposure.
• Previous research suggests associations between certain finger length ratios and health outcomes, including conditions potentially impacting lifespan.

Purpose of the Study:

• To investigate differences in finger length ratio prevalence between longevity populations (Abkhazians, Azerbaijanis, Georgians) and a nonlongevity population (Russians).
• To compare finger length ratio patterns within an ethnic group (Abkhazians) by contrasting longevity and nonlongevity samples.

Main Methods:

• A cross-sectional observational study design was employed.
• Prevalence of finger length ratios (type 1 - feminine, type 3 - masculine) was compared between longevity and nonlongevity samples across different ethnic groups.

Main Results:

• Longevity populations showed a significantly lower prevalence of the type 1 (feminine) finger length ratio and a higher prevalence of the type 3 (masculine) ratio compared to the Russian nonlongevity sample (P < .001).
• These significant differences were observed in both males and females and were also evident when comparing longevity and nonlongevity samples within the Abkhazian ethnic group.
• Nonlongevity samples, both male and female, exhibited a significantly higher prevalence of type 1 and lower prevalence of type 3 ratios (P < .001).

Conclusions:

• Finger length ratio patterns differ between longevity and nonlongevity populations, with longevity groups favoring a more masculine ratio (lower type 1, higher type 3).
• The observed differences suggest a potential link between finger length ratio and factors influencing lifespan.
• The association of type 1 ratio with morbidities that shorten lifespan provides a plausible explanation for the findings in longevity populations.