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Mapping Viral Susceptibility Loci in Mice.
Melissa Kane1, Tatyana V Golovkina2
1Center for Microbial Pathogenesis, Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224, USA.
Annual Review of Virology
|October 1, 2019
Summary
Genetic studies in mice reveal key host defense genes against viral infections. Understanding these genetic factors aids personalized strategies for preventing and treating viral diseases.
Area of Science:
- Virology
- Immunology
- Genetics
Background:
- Genetic factors influencing susceptibility and resistance to viral infections are crucial for understanding host-pathogen interactions.
- The mouse model is a powerful system for genetic studies, enabling the identification of critical host genes before human studies.
Purpose of the Study:
- To review discoveries of genetic alleles impacting viral infection outcomes using mouse genetic mapping.
- To highlight the role of innate and adaptive immunity genes in host defense against various viruses.
Main Methods:
- Utilizing genetic mapping tools in mice to identify genes involved in viral infection.
- Reviewing existing literature on genetic discoveries related to virus-host interactions.
Main Results:
- Identification of numerous host genes, including innate and adaptive immunity factors, that influence resistance or susceptibility to viruses.
- Insights gained into host defense mechanisms against herpesviruses, flaviviruses, retroviruses, and coronaviruses.
Conclusions:
- Genetic studies in mice have significantly advanced our understanding of virus-host interactions.
- Identifying genetic mechanisms of infectious disease outcomes is vital for developing personalized treatments and prevention strategies.
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