Related Experiment Video
Updated: Jan 3, 2026
08:23
Culture Methods to Determine the Limit of Detection and Survival in Transport Media of Campylobacter Jejuni in Human Fecal Specimens
Published on: March 10, 2020
12.1K
Postinfectious Irritable Bowel Syndrome After Campylobacter Infection
Elaine J Scallan Walter1, Stacy M Crim2, Beau B Bruce2
1Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, Colorado, USA.
The American Journal of Gastroenterology
|October 1, 2019
Summary
Campylobacter infection significantly increases the risk of developing postinfectious irritable bowel syndrome (PI-IBS). This study quanties the incidence of PI-IBS following Campylobacter infection in the US.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Epidemiology
Background:
- Postinfectious irritable bowel syndrome (PI-IBS) is a recognized complication following gastrointestinal infections.
- Campylobacter infection is a common cause of bacterial gastroenteritis and a potential trigger for PI-IBS.
Purpose of the Study:
- To estimate the incidence of PI-IBS in the United States following Campylobacter infection.
- To quantify the risk of developing IBS after a confirmed Campylobacter infection.
Main Methods:
- A retrospective cohort study using the MarketScan Research Commercial Claims and Encounters Database (2010-2014).
- Patients with Campylobacter infection (cases) were matched to uninfected individuals (non-cases) based on age, sex, and enrollment duration.
- Incidence of new IBS diagnoses was assessed at 1 year post-infection.
Main Results:
- The 1-year incidence rate of IBS was 33.1 per 1,000 among Campylobacter cases versus 5.9 per 1,000 among non-cases (Risk Ratio: 5.6).
- Adjusted Cox proportional hazard ratio for IBS development was 4.6.
- Excluding early diagnoses (within 90 days), the 1-year IBS incidence was 16.7 per 1,000 for cases and 3.9 per 1,000 for non-cases (Risk Ratio: 4.3).
Conclusions:
- Campylobacter infection substantially elevates the risk of developing IBS.
- The findings highlight the significant burden of PI-IBS associated with Campylobacter infections and underscore the need for its consideration in public health assessments.
