Prevention of osteoporosis in cystic fibrosis
Frédérique Chedevergne1, Isabelle Sermet-Gaudelus1,2,3
1Centre de Référence Maladie Rare, Mucoviscidose et maladies du CFTR, Site Constitutif Pediatrique, Hôpital Necker-Enfants Malades.
Purpose Of Review:
The increased life span of patients with cystic fibrosis has lead to the detection of new complications. Osteopenia is present in up to 50% of adult patients with cystic fibrosis, and osteoporosis in 10-34% and can cause a difficult management problem.
Recent Findings:
In children, defects in bone health become apparent generally at adolescence because of suboptimall bone peak mass achievement. Malnutrition, inflammation, vitamin D and vitamin K deficiency, altered sex hormone production, glucocorticoid therapy, and physical inactivity potentiate poor bone health.
Summary:
Monitoring bone mineral density and preventive care of osteoporosis are necessary from childhood to minimize cystic fibrosis-related bone disease in adult cystic fibrosis patients.
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